The Antinociceptive Effect of Adalimumab, a TNF-Alpha Inhibitor, in a Mice Model of Inflammatory Pain

The aim of this study, evaluate the nociceptive effect adalimumab, a TNF-alpha inhibitor, on formalin-induced inflammatory pain in mice. antinociceptive activity adalimumab was determined adult male BALB-C mice (6 each group) by model and hot plate test applied. Diclofenac, which we used as positive control, showed anti-nociceptive both phases formalin test. at thirtieth minute statistically significantly different. Adalimumab not effective neuronal phase but an phase. Changes due to did reach statistical significance. findings study that applied single dose, had This result indicated peripheral analgesic is stronger.